Base de dados : HANSEN Pesquisa : MUCOSA NASAL/IMUNOL [Descritor de assunto] Referências encontradas : 3 [refinar] Mostrando: 1 .. 3   no formato [Detalhado]

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Id: 27234 Autor: Fokkens, Wytske J; Trenite, Gijs J. Nolst; Virmond, Marcus; KleinJan, Alex; Andrade, Vera L. G; Baar, Nino G. van; Naafs, Ben. Título: The nose in leprosy: Immunohistology of the nasal mucosa. Fonte: Int. J. Lepr;66(3):328-339, Sept. 1998. ilus, tab. Resumo: A detailed study of the nose was undertaken in 40 leprosy patients with different classifications of leprosy and different durations of disease at two hospitals in Brazil. This manuscript describes the immunohistochemical data on cellular infiltrates in the nasal biopsies of those patients. It was surprising that the damage to the whole depth of the nasal mucosa, epithelium and lamina propria was considerable, as was the case in the nasal mucosa which looked relatively normal during clinical inspection. The epithelium showed large holes which looked like very extended goblet cells. Very obvious was the lack of vasoconstriction after cocaine application, and the vessels also showed a lack of staining with factor VIII, possibly indicating a disruption of the endothelium. The number of neurofilaments was extensively reduced in all leprosy groups compared to normal controls. As in the skin, an increased number of CD68+ cells was found in the lamina propria of the nasal mucosa of the lepromatous patients. Contrary to findings in the skin, in the nasal mucosa of the borderline/lepromatous patients the number of CD4+ cells was increased and the number of CD8+ cells was decreased compared to normal controls. The number of CD8+ cells tended to be more reduced when the history of leprosy was longer. It is not clear as yet whether the reduced numbers of CD8+ cells are acquired during infection or whether persons with a low number of CD8+ cells in the nose might have a higher risk of acquiring leprosy. (AU)^ien. Descritores: Hanseníase/imunol Hanseníase/patol Mucosa Nasal/imunol Mucosa Nasal/patol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a03.pdf - en. Localização: BR191.1

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Id: 25524 Autor: Patrocinio, Lucas Gomes; Goulart, Isabela Maria Bernardes; Goulart, Luiz Ricardo; Patrocinio, Jose Antonio; Ferreira, Frederico Regerio; Fleury, Raul Negrao Título: Detection of Mycobacterium leprae in nasal mucosa biopsies by the polymerase chain reaction ..- Fonte: s.l; s.n; 2005. 6 p. ilus, tab. Resumo: Several discoveries about leprosy indicate that Mycobacterium leprae transmission mainly accurs by inhalation, and the nose is major port of entry and exit. The present study evaluated the clinical application of PCR for detection of M. leprae DNA in nasal mucosa biopsies in untreated leprosy patients (52) and their contacts (99) from the State Reference Center in Sanitary Dermatology and Leprosy, Uberlandia, MG, Brazil. PCR detection of a 372-base pair DNA fragment from M. leprae was accomplished in 36 (69.2%) patients, from which 34 (91.9%) of them were multibacillaries. Furhermore, PCR was positive in 3 (16.7%) of 18 slit-skin smear negative, 4 (25.0%) of 16 skin lesion BI negative, 8 (33.3%) of 24 nasal mucosa BI negative patients, and 10 of 99 contacts (10.1%). The presence of bacilli in 10.1% of the contats may potentially reflect an occult leprosy, and reflect an occult leprosy, and these patients must be accompanied, followed by a chemoprophylaxy treatment. Considering all PCR results against clinical and BI classification of patients and controls, we have found a sensitivity of 69.2%, a specificity of 89.9% and an accuracy of 82.8%. It has been demonstrated here through PCR of nasal biopsies that the bacillus invades the mucosa, passing through the nasal inferior turbinate to reach peripheral blood. Therefore, the molecular investigation of invasive nasal biopsies by PCR tests has proven to be useful in defining patients of higher risk of transmission and risk-group contacts, which is an important step ti reach the World Health Organization objective towards the elimination of leprosy as a public health problem (AU). Descritores: MUCOSA NASAL/imunol MUCOSA NASAL/les MUCOSA NASAL/microbiol MUCOSA NASAL/patol MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/ultraest REACAO EM CADEIA DA POLIMERASE/estatíst REACAO EM CADEIA DA POLIMERASE/tend REACAO EM CADEIA DA POLIMERASE/util - BIOPSIA/estatíst  BIOPSIA/tend  BIOPSIA/util  HANSENIASE/clas  HANSENIASE/diag  HANSENIASE/microbiol  HANSENIASE/patol Limites: HUMANO Localização: BR191.a; 09307/s

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Id: 14217 Autor: Ramaprasad, P; Cree, I. A; Oluwole, M; Samson, P. D Título: Development of a mucosal challenge test for leprosy using leprosin A ..- Fonte: s.l; s.n; 1995. 8 p. tab, graf. Descritores: ADOLESCENCIA ANTIGENOS DE BACTÉRIAS ELISA IGA IGA SECRETORA MYCOBACTERIUM LEPRAE MUCOSA NASAL MUCOSA NASAL TESTES DE PROVOCAÇAO NASAL SALIVA TUBERCULINA HANSENIASE Localização: BR191.1; 06919/s

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